4LFX

X-ray structure of the adduct between hen egg white lysozyme and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers

4LFX の概要

• エントリーDOI: 10.2210/pdb4lfx/pdb
• 関連するPDBエントリー: 4J1A 4J1B 4LFP 4LGK
• 分子名称: Lysozyme C, CHLORIDE ION, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: Gallus gallus (bantam,chickens)
• 細胞内の位置: Secreted: P00698
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14657.48

構造登録者

Vergara, A.,Merlino, A. (登録日: 2013-06-27, 公開日: 2013-10-02, 最終更新日: 2024-10-30)

主引用文献

Messori, L.,Scaletti, F.,Massai, L.,Cinellu, M.A.,Gabbiani, C.,Vergara, A.,Merlino, A.
The mode of action of anticancer gold-based drugs: a structural perspective.
Chem.Commun.(Camb.), 49:10100-10102, 2013

PubMed Abstract: The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.

PubMed: 24045294
DOI: 10.1039/c3cc46400h

実験手法

X-RAY DIFFRACTION (2.1 Å)