4LGK

X-ray structure of the adduct between hen egg white lysozyme and Au2Phen, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers

Summary for 4LGK

Entry DOI	10.2210/pdb4lgk/pdb
Related	4J1A 4J1B 4LFP 4LFX
Descriptor	Lysozyme C, GOLD ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	hydrolase
Biological source	Gallus gallus (bantam,chickens)
Total number of polymer chains	1
Total formula weight	14634.49
Authors	Vergara, A.,Merlino, A. (deposition date: 2013-06-28, release date: 2013-10-02, Last modification date: 2024-10-30)
Primary citation	Messori, L.,Scaletti, F.,Massai, L.,Cinellu, M.A.,Gabbiani, C.,Vergara, A.,Merlino, A. The mode of action of anticancer gold-based drugs: a structural perspective. Chem.Commun.(Camb.), 49:10100-10102, 2013 Cited by PubMed Abstract: The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes. PubMed: 24045294 DOI: 10.1039/c3cc46400h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation