4LF3

Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

Summary for 4LF3

• Entry DOI: 10.2210/pdb4lf3/pdb
• Related: 4ERS 4LEX
• Descriptor: Fab heavy chain, Fab light chain, Glucagon receptor, ... (4 entities in total)
• Functional Keywords: fab fragment, gcgr, immune system
• Biological source: Mus musculus (mouse); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P47871
• Total number of polymer chains: 6
• Total formula weight: 119231.48

Authors

Murray, J.M.,Mukund, S. (deposition date: 2013-06-26, release date: 2013-11-13, Last modification date: 2023-09-20)

• Primary citation: Mukund, S.,Shang, Y.,Clarke, H.J.,Madjidi, A.,Corn, J.E.,Kates, L.,Kolumam, G.,Chiang, V.,Luis, E.,Murray, J.,Zhang, Y.,Hotzel, I.,Koth, C.M.,Allan, B.B.; Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.; J.Biol.Chem., 288:36168-36178, 2013; PubMed: 24189067; DOI: 10.1074/jbc.M113.496984

Experimental method

X-RAY DIFFRACTION (2.735 Å)