4LF3

Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004930	molecular_function	G protein-coupled receptor activity
C	0004967	molecular_function	glucagon receptor activity
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0016020	cellular_component	membrane
F	0004930	molecular_function	G protein-coupled receptor activity
F	0004967	molecular_function	glucagon receptor activity
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR423-HIS429
A	TYR192-HIS198

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site_id	PS00649
Number of Residues	25
Details	G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDkys.CWpdTpanttanisCP

Chain	Residue	Details
C	CYS58-PRO82

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28514451

Chain	Residue	Details
C	ASN46
C	ASN59
F	ASN46
F	ASN59

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:28514451, ECO:0007744|PDB:4ERS

Chain	Residue	Details
C	ASN74
C	ASN78
F	ASN74
F	ASN78

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