4LEV

Structure of human cGAS

Summary for 4LEV

• Entry DOI: 10.2210/pdb4lev/pdb
• Related: 4LEW 4LEy 4LEz
• Descriptor: Cyclic GMP-AMP synthase, ZINC ION (3 entities in total)
• Functional Keywords: ntase, dna sensor, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytosol: Q8N884
• Total number of polymer chains: 2
• Total formula weight: 86897.19

Authors

Li, P. (deposition date: 2013-06-26, release date: 2013-12-25, Last modification date: 2014-01-08)

• Primary citation: Li, X.,Shu, C.,Yi, G.,Chaton, C.T.,Shelton, C.L.,Diao, J.,Zuo, X.,Kao, C.C.,Herr, A.B.,Li, P.; Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization.; Immunity, 39:1019-1031, 2013; PubMed: 24332030; DOI: 10.1016/j.immuni.2013.10.019

Experimental method

X-RAY DIFFRACTION (1.952 Å)