4LEO

Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3)

Summary for 4LEO

Entry DOI	10.2210/pdb4leo/pdb
Descriptor	RG7116 Fab heavy chain, RG7116 Fab light chain, Receptor tyrosine-protein kinase erbB-3, ... (6 entities in total)
Functional Keywords	fab fragment, therapeutic antibody, her3 receptor, transferase-immune system complex, transferase/immune system
Biological source	Mus musculus (mouse) More
Total number of polymer chains	3
Total formula weight	118509.99
Authors	Schiller, C.B.,Hopfner, K.P. (deposition date: 2013-06-26, release date: 2013-07-10, Last modification date: 2020-07-29)
Primary citation	Mirschberger, C.,Schiller, C.B.,Schraml, M.,Dimoudis, N.,Friess, T.,Gerdes, C.A.,Reiff, U.,Lifke, V.,Hoelzlwimmer, G.,Kolm, I.,Hopfner, K.P.,Niederfellner, G.,Bossenmaier, B. RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation. Cancer Res., 73:5183-5194, 2013 Cited by PubMed: 23780344 DOI: 10.1158/0008-5472.CAN-13-0099 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.64 Å)

Structure validation