4LEO
Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RG7116 Fab heavy chain | polymer | 227 | 24369.3 | 1 | Mus musculus (mouse) | ||
| 2 | B (B) | RG7116 Fab light chain | polymer | 220 | 24231.8 | 1 | Mus musculus (mouse) | ||
| 3 | C (C) | Receptor tyrosine-protein kinase erbB-3 | polymer | 621 | 68378.5 | 1 | UniProt (P21860) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | Her3 (ERBB3) extracellular domains, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3 |
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E, F, G, H, I (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 6 | J, K, L (A, B, C) | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
C: 1 - 612 (UniProt: P21860)
| PDB | External Database | Details |
|---|---|---|
| Ala 613 | - | expression tag |
| Ala 614 | - | expression tag |
| Ala 615 | - | expression tag |
| Leu 616 | - | expression tag |
| Glu 617 | - | expression tag |
| Val 618 | - | expression tag |
| Leu 619 | - | expression tag |
| Phe 620 | - | expression tag |
| Gln 621 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 116979.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1106.0 | |
| All* | Total formula weight | 118510.0 |
