4L9I
Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine
Summary for 4L9I
Entry DOI | 10.2210/pdb4l9i/pdb |
Related | 3C50 3V5W 4MK0 |
Descriptor | Rhodopsin kinase, Paroxetine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total) |
Functional Keywords | agc family kinase, ser/thr kinase, rgs homology domain, g protein coupled receptor kinase, grk, grk1, rhodopsin kinase, ssri, hydrolyase, gpcr, phosphorylation, transferase, membrane protein-inhibitor complex, membrane protein/inhibitor |
Biological source | Bos taurus (bovine) |
Cellular location | Membrane ; Lipid- anchor : P28327 |
Total number of polymer chains | 2 |
Total formula weight | 115635.99 |
Authors | Homan, K.T.,Tesmer, J.J.G. (deposition date: 2013-06-18, release date: 2014-01-22, Last modification date: 2023-09-20) |
Primary citation | Homan, K.T.,Wu, E.,Wilson, M.W.,Singh, P.,Larsen, S.D.,Tesmer, J.J. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol.Pharmacol., 85:237-248, 2014 Cited by PubMed: 24220010DOI: 10.1124/mol.113.089631 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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