4L9I

Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine

4L9I の概要

• エントリーDOI: 10.2210/pdb4l9i/pdb
• 関連するPDBエントリー: 3C50 3V5W 4MK0
• 分子名称: Rhodopsin kinase, Paroxetine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: agc family kinase, ser/thr kinase, rgs homology domain, g protein coupled receptor kinase, grk, grk1, rhodopsin kinase, ssri, hydrolyase, gpcr, phosphorylation, transferase, membrane protein-inhibitor complex, membrane protein/inhibitor
• 由来する生物種: Bos taurus (bovine)
• 細胞内の位置: Membrane ; Lipid- anchor : P28327
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115635.99

構造登録者

Homan, K.T.,Tesmer, J.J.G. (登録日: 2013-06-18, 公開日: 2014-01-22, 最終更新日: 2023-09-20)

• 主引用文献: Homan, K.T.,Wu, E.,Wilson, M.W.,Singh, P.,Larsen, S.D.,Tesmer, J.J.; Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.; Mol.Pharmacol., 85:237-248, 2014; PubMed: 24220010; DOI: 10.1124/mol.113.089631

実験手法

X-RAY DIFFRACTION (2.32 Å)