4L8V

Crystal Structure of A12K/D35S mutant myo-inositol dehydrogenase from Bacillus subtilis with bound cofactor NADP

Summary for 4L8V

Entry DOI	10.2210/pdb4l8v/pdb
Related	3MZ0 3NT2 3NT4 3NT5 3NTO 3NTQ 4L9R
Descriptor	Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	cofactor, binding sites, catalysis, hydrogen bonding, inositol, kinetics, sugar alcohol dehydrogenase, rossmann fold, nadp binding, oxidoreductase
Biological source	Bacillus subtilis subsp. subtilis
Total number of polymer chains	4
Total formula weight	153871.22
Authors	Bertwistle, D.,Sanders, D.A.R.,Palmer, D.R.J. (deposition date: 2013-06-18, release date: 2013-09-04, Last modification date: 2023-09-20)
Primary citation	Zheng, H.,Bertwistle, D.,Sanders, D.A.,Palmer, D.R. Converting NAD-Specific Inositol Dehydrogenase to an Efficient NADP-Selective Catalyst, with a Surprising Twist. Biochemistry, 52:5876-5883, 2013 Cited by PubMed: 23952058 DOI: 10.1021/bi400821s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation