4L8V
Crystal Structure of A12K/D35S mutant myo-inositol dehydrogenase from Bacillus subtilis with bound cofactor NADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019310 | biological_process | inositol catabolic process |
| A | 0050112 | molecular_function | inositol 2-dehydrogenase (NAD+) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019310 | biological_process | inositol catabolic process |
| B | 0050112 | molecular_function | inositol 2-dehydrogenase (NAD+) activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019310 | biological_process | inositol catabolic process |
| C | 0050112 | molecular_function | inositol 2-dehydrogenase (NAD+) activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019310 | biological_process | inositol catabolic process |
| D | 0050112 | molecular_function | inositol 2-dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAP A 401 |
| Chain | Residue |
| A | LYS12 |
| A | PRO98 |
| A | GLY124 |
| A | MET126 |
| A | HIS176 |
| A | TRP272 |
| A | TYR280 |
| A | HOH535 |
| A | ILE13 |
| A | THR73 |
| A | SER74 |
| A | TRP75 |
| A | GLY76 |
| A | HIS79 |
| A | GLU96 |
| A | LYS97 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 402 |
| Chain | Residue |
| A | ASP130 |
| A | SER131 |
| A | GLY132 |
| A | PRO251 |
| A | ARG275 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 403 |
| Chain | Residue |
| A | TYR129 |
| A | ASP130 |
| A | SER131 |
| A | ALA278 |
| A | ALA279 |
| A | HOH532 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE NAP B 400 |
| Chain | Residue |
| B | GLY11 |
| B | LYS12 |
| B | ILE13 |
| B | THR73 |
| B | SER74 |
| B | TRP75 |
| B | GLY76 |
| B | HIS79 |
| B | GLU96 |
| B | LYS97 |
| B | GLY124 |
| B | MET126 |
| B | TRP272 |
| B | TYR280 |
| B | HOH508 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NAP C 401 |
| Chain | Residue |
| B | LYS330 |
| B | GLU331 |
| C | GLY11 |
| C | LYS12 |
| C | ILE13 |
| C | TRP75 |
| C | HIS79 |
| C | GLU96 |
| C | LYS97 |
| C | PRO98 |
| C | GLY124 |
| C | MET126 |
| C | TRP272 |
| C | TYR280 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 402 |
| Chain | Residue |
| C | SER191 |
| C | GLN193 |
| C | VAL214 |
| C | GLU216 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 403 |
| Chain | Residue |
| C | ASP130 |
| C | GLY132 |
| C | ARG275 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAP D 401 |
| Chain | Residue |
| D | THR10 |
| D | GLY11 |
| D | LYS12 |
| D | ILE13 |
| D | SER35 |
| D | ASN37 |
| D | THR73 |
| D | SER74 |
| D | TRP75 |
| D | HIS79 |
| D | GLU96 |
| D | LYS97 |
| D | PRO98 |
| D | GLY124 |
| D | MET126 |
| D | HIS176 |
| D | TRP272 |
| D | TYR280 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 402 |
| Chain | Residue |
| D | ASP130 |
| D | SER131 |
| D | GLY132 |
| D | ARG275 |
