4L3E
The complex between high affinity TCR DMF5(alpha-D26Y,beta-L98W) and human Class I MHC HLA-A2 with the bound MART-1(26-35)(A27L) peptide
Summary for 4L3E
Entry DOI | 10.2210/pdb4l3e/pdb |
Related | 3QDG 3QDJ 3QDM 3QEQ 3QEU |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma antigen recognized by T-cells 1, ... (6 entities in total) |
Functional Keywords | receptors, membrane, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769 Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655 |
Total number of polymer chains | 5 |
Total formula weight | 93775.09 |
Authors | Hellman, L.M. (deposition date: 2013-06-05, release date: 2014-06-11, Last modification date: 2014-08-27) |
Primary citation | Pierce, B.G.,Hellman, L.M.,Hossain, M.,Singh, N.K.,Vander Kooi, C.W.,Weng, Z.,Baker, B.M. Computational design of the affinity and specificity of a therapeutic T cell receptor. PLOS COMPUT.BIOL., 10:e1003478-e1003478, 2014 Cited by PubMed: 24550723DOI: 10.1371/journal.pcbi.1003478 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.557 Å) |
Structure validation
Download full validation report