4L3E
The complex between high affinity TCR DMF5(alpha-D26Y,beta-L98W) and human Class I MHC HLA-A2 with the bound MART-1(26-35)(A27L) peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 275 | 31854.2 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C (C) | Melanoma antigen recognized by T-cells 1 | polymer | 10 | 985.2 | 1 | UniProt (Q16655) | Homo sapiens | MART-1, Antigen LB39-AA, Antigen SK29-AA, Protein Melan-A |
| 4 | D (D) | DMF5 alpha chain | polymer | 199 | 22055.3 | 1 | Homo sapiens (human) | ||
| 5 | E (E) | DMF5 beta chain | polymer | 242 | 27001.0 | 1 | Homo sapiens (human) | ||
| 6 | F, G, H, I, J (A, B, C, D, E) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
C: 1 - 10 (UniProt: Q16655)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Leu 2 | Ala 27 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 93775.1 | |
| All* | Total formula weight | 93775.1 |
