4KZ8

Crystal structure of AmpC beta-lactamase in complex with fragment 20 (1,3-diethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione)

Summary for 4KZ8

Entry DOI	10.2210/pdb4kz8/pdb
Related	4KZ3 4KZ4 4KZ5 4KZ6 4KZ7 4KZ9 4KZA 4KZB
Descriptor	Beta-lactamase, 1,3-diethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	ampc beta-lactamase, class c, hydrolase, cephalosporinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli
Cellular location	Periplasm: P00811
Total number of polymer chains	2
Total formula weight	80071.85
Authors	Eidam, O.,Barelier, S.,Fish, I.,Shoichet, B.K. (deposition date: 2013-05-29, release date: 2014-05-21, Last modification date: 2023-09-20)
Primary citation	Barelier, S.,Eidam, O.,Fish, I.,Hollander, J.,Figaroa, F.,Nachane, R.,Irwin, J.J.,Shoichet, B.K.,Siegal, G. Increasing chemical space coverage by combining empirical and computational fragment screens. Acs Chem.Biol., 9:1528-1535, 2014 Cited by PubMed: 24807704 DOI: 10.1021/cb5001636 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.282 Å)

Structure validation