4KZ7
Crystal structure of AmpC beta-lactamase in complex with fragment 16 ((1R,4S)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid)
Summary for 4KZ7
Entry DOI | 10.2210/pdb4kz7/pdb |
Related | 4KZ3 4KZ4 4KZ5 4KZ6 4KZ8 4KZ9 4KZA 4KZB |
Descriptor | Beta-lactamase, (1R,4S)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | ampc beta-lactamase, class c, hydrolase, cephalosporinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli |
Cellular location | Periplasm: P00811 |
Total number of polymer chains | 2 |
Total formula weight | 79667.25 |
Authors | Eidam, O.,Barelier, S.,Fish, I.,Shoichet, B.K. (deposition date: 2013-05-29, release date: 2014-05-21, Last modification date: 2023-09-20) |
Primary citation | Barelier, S.,Eidam, O.,Fish, I.,Hollander, J.,Figaroa, F.,Nachane, R.,Irwin, J.J.,Shoichet, B.K.,Siegal, G. Increasing chemical space coverage by combining empirical and computational fragment screens. Acs Chem.Biol., 9:1528-1535, 2014 Cited by PubMed: 24807704DOI: 10.1021/cb5001636 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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