4KY4

Crystal structure of non-classical TS inhibitor 2 in complex with Toxoplasma gondii TS-DHFR

Summary for 4KY4

• Entry DOI: 10.2210/pdb4ky4/pdb
• Related: 4EIL 4KYA
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Aminopterin, ... (5 entities in total)
• Functional Keywords: synthase, bifunctional, oxidoreductase, transferase
• Biological source: Toxoplasma gondii
• Total number of polymer chains: 8
• Total formula weight: 565160.24

Authors

Sharma, H.,Anderson, K.S. (deposition date: 2013-05-28, release date: 2014-08-06, Last modification date: 2023-09-20)

• Primary citation: Zaware, N.,Sharma, H.,Yang, J.,Devambatla, R.K.,Queener, S.F.,Anderson, K.S.,Gangjee, A.; Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.; ACS Med Chem Lett, 4:1148-1151, 2013; PubMed: 24470841; DOI: 10.1021/ml400208v

Experimental method

X-RAY DIFFRACTION (2.79 Å)