4KY4
Crystal structure of non-classical TS inhibitor 2 in complex with Toxoplasma gondii TS-DHFR
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 610 | 68842.7 | 8 | UniProt (Q07422) Pfam (PF00186) Pfam (PF00303) In PDB | Toxoplasma gondii | DHFR-TS, Dihydrofolate reductase, Thymidylate synthase |
2 | F, G, A, H, B... | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 8 | Chemie (UMP) | |||
3 | F, G, A, H, B... | Aminopterin | non-polymer | 440.4 | 8 | Chemie (04J) | |||
4 | E, F, G, A, H... | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 8 | Chemie (NDP) | |||
5 | E, F, G, A, H... | 2-amino-5-(phenylsulfanyl)-3,9-dihydro-4H-pyrimido[4,5-b]indol-4-one | non-polymer | 308.4 | 8 | Chemie (1UE) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 550741.2 | |
Non-Polymers* | Number of molecules | 32 |
Total formula weight | 14419.0 | |
All* | Total formula weight | 565160.2 |