4KY4
Crystal structure of non-classical TS inhibitor 2 in complex with Toxoplasma gondii TS-DHFR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0032259 | biological_process | methylation |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004146 | molecular_function | dihydrofolate reductase activity |
| C | 0004799 | molecular_function | thymidylate synthase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005829 | cellular_component | cytosol |
| C | 0006231 | biological_process | dTMP biosynthetic process |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0009165 | biological_process | nucleotide biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| C | 0032259 | biological_process | methylation |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004146 | molecular_function | dihydrofolate reductase activity |
| D | 0004799 | molecular_function | thymidylate synthase activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005829 | cellular_component | cytosol |
| D | 0006231 | biological_process | dTMP biosynthetic process |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0009165 | biological_process | nucleotide biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| D | 0032259 | biological_process | methylation |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004146 | molecular_function | dihydrofolate reductase activity |
| E | 0004799 | molecular_function | thymidylate synthase activity |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005829 | cellular_component | cytosol |
| E | 0006231 | biological_process | dTMP biosynthetic process |
| E | 0006730 | biological_process | one-carbon metabolic process |
| E | 0008168 | molecular_function | methyltransferase activity |
| E | 0009165 | biological_process | nucleotide biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| E | 0032259 | biological_process | methylation |
| E | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004146 | molecular_function | dihydrofolate reductase activity |
| F | 0004799 | molecular_function | thymidylate synthase activity |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005829 | cellular_component | cytosol |
| F | 0006231 | biological_process | dTMP biosynthetic process |
| F | 0006730 | biological_process | one-carbon metabolic process |
| F | 0008168 | molecular_function | methyltransferase activity |
| F | 0009165 | biological_process | nucleotide biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| F | 0032259 | biological_process | methylation |
| F | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004146 | molecular_function | dihydrofolate reductase activity |
| G | 0004799 | molecular_function | thymidylate synthase activity |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005829 | cellular_component | cytosol |
| G | 0006231 | biological_process | dTMP biosynthetic process |
| G | 0006730 | biological_process | one-carbon metabolic process |
| G | 0008168 | molecular_function | methyltransferase activity |
| G | 0009165 | biological_process | nucleotide biosynthetic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| G | 0032259 | biological_process | methylation |
| G | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004146 | molecular_function | dihydrofolate reductase activity |
| H | 0004799 | molecular_function | thymidylate synthase activity |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005829 | cellular_component | cytosol |
| H | 0006231 | biological_process | dTMP biosynthetic process |
| H | 0006730 | biological_process | one-carbon metabolic process |
| H | 0008168 | molecular_function | methyltransferase activity |
| H | 0009165 | biological_process | nucleotide biosynthetic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016740 | molecular_function | transferase activity |
| H | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| H | 0032259 | biological_process | methylation |
| H | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE UMP A 701 |
| Chain | Residue |
| A | CYS489 |
| B | ARG469 |
| B | ARG470 |
| A | HIS490 |
| A | GLN509 |
| A | ARG510 |
| A | SER511 |
| A | ASP513 |
| A | ASN521 |
| A | HIS551 |
| A | TYR553 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 04J A 702 |
| Chain | Residue |
| A | VAL8 |
| A | VAL9 |
| A | ALA10 |
| A | ASP31 |
| A | PHE32 |
| A | PHE35 |
| A | SER36 |
| A | PHE91 |
| A | LEU94 |
| A | ARG97 |
| A | THR172 |
| A | NDP703 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NDP A 703 |
| Chain | Residue |
| A | VAL9 |
| A | ALA10 |
| A | ILE17 |
| A | GLY18 |
| A | ILE19 |
| A | ASN21 |
| A | GLY22 |
| A | GLY80 |
| A | ARG81 |
| A | LYS82 |
| A | THR83 |
| A | SER86 |
| A | VAL102 |
| A | SER103 |
| A | SER104 |
| A | GLY153 |
| A | ALA154 |
| A | GLY155 |
| A | TYR157 |
| A | VAL182 |
| A | 04J702 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1UE A 704 |
| Chain | Residue |
| A | ILE402 |
| A | TRP403 |
| A | ASN406 |
| A | ASP513 |
| A | LEU516 |
| A | GLY517 |
| A | MET608 |
| A | ALA609 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE UMP B 701 |
| Chain | Residue |
| A | ARG469 |
| A | ARG470 |
| B | CYS489 |
| B | HIS490 |
| B | GLN509 |
| B | ARG510 |
| B | SER511 |
| B | ASP513 |
| B | ASN521 |
| B | HIS551 |
| B | TYR553 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 04J B 702 |
| Chain | Residue |
| B | VAL8 |
| B | VAL9 |
| B | ALA10 |
| B | ASP31 |
| B | PHE32 |
| B | PHE35 |
| B | SER36 |
| B | PHE91 |
| B | ARG97 |
| B | THR172 |
| B | NDP703 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NDP B 703 |
| Chain | Residue |
| B | VAL9 |
| B | ALA10 |
| B | ILE17 |
| B | GLY18 |
| B | ILE19 |
| B | ASN21 |
| B | GLY22 |
| B | LEU23 |
| B | TRP25 |
| B | GLY80 |
| B | ARG81 |
| B | LYS82 |
| B | THR83 |
| B | SER86 |
| B | VAL102 |
| B | SER103 |
| B | SER104 |
| B | SER105 |
| B | ALA128 |
| B | GLY153 |
| B | ALA154 |
| B | VAL182 |
| B | 04J702 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1UE B 704 |
| Chain | Residue |
| B | ASP513 |
| B | LEU516 |
| B | GLY517 |
| B | MET608 |
| B | ALA609 |
| B | TRP403 |
| B | ASN406 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE UMP C 701 |
| Chain | Residue |
| C | CYS489 |
| C | HIS490 |
| C | GLN509 |
| C | ARG510 |
| C | SER511 |
| C | ASP513 |
| C | ASN521 |
| C | HIS551 |
| C | TYR553 |
| D | ARG469 |
| D | ARG470 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 04J C 702 |
| Chain | Residue |
| C | VAL8 |
| C | VAL9 |
| C | ASP31 |
| C | PHE32 |
| C | PHE35 |
| C | SER36 |
| C | PHE91 |
| C | LEU94 |
| C | ARG97 |
| C | THR172 |
| C | NDP703 |
| site_id | BC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NDP C 703 |
| Chain | Residue |
| C | VAL9 |
| C | ALA10 |
| C | ILE17 |
| C | GLY18 |
| C | ILE19 |
| C | ASN21 |
| C | GLY22 |
| C | ARG81 |
| C | LYS82 |
| C | THR83 |
| C | SER86 |
| C | VAL102 |
| C | SER103 |
| C | SER104 |
| C | GLY153 |
| C | ALA154 |
| C | GLY155 |
| C | LEU156 |
| C | TYR157 |
| C | VAL182 |
| C | 04J702 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1UE C 704 |
| Chain | Residue |
| C | ILE402 |
| C | TRP403 |
| C | ASN406 |
| C | ASP513 |
| C | LEU516 |
| C | GLY517 |
| C | MET608 |
| C | ALA609 |
| site_id | BC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE UMP D 701 |
| Chain | Residue |
| C | ARG469 |
| C | ARG470 |
| D | CYS489 |
| D | HIS490 |
| D | GLN509 |
| D | ARG510 |
| D | SER511 |
| D | ASP513 |
| D | ASN521 |
| D | HIS551 |
| D | TYR553 |
| D | 1UE704 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 04J D 702 |
| Chain | Residue |
| D | VAL8 |
| D | VAL9 |
| D | ALA10 |
| D | ASP31 |
| D | PHE32 |
| D | PHE35 |
| D | SER36 |
| D | PHE91 |
| D | ARG97 |
| D | NDP703 |
| site_id | BC6 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NDP D 703 |
| Chain | Residue |
| D | VAL9 |
| D | ALA10 |
| D | ILE17 |
| D | GLY18 |
| D | ILE19 |
| D | ASN21 |
| D | GLY22 |
| D | LEU23 |
| D | TRP25 |
| D | GLY80 |
| D | ARG81 |
| D | LYS82 |
| D | THR83 |
| D | SER86 |
| D | VAL102 |
| D | SER103 |
| D | SER104 |
| D | SER105 |
| D | ALA128 |
| D | GLY153 |
| D | ALA154 |
| D | GLY155 |
| D | TYR157 |
| D | VAL182 |
| D | 04J702 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1UE D 704 |
| Chain | Residue |
| D | TRP403 |
| D | ASN406 |
| D | ASP513 |
| D | LEU516 |
| D | GLY517 |
| D | MET608 |
| D | ALA609 |
| D | UMP701 |
| site_id | BC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE UMP E 701 |
| Chain | Residue |
| E | CYS489 |
| E | HIS490 |
| E | GLN509 |
| E | ARG510 |
| E | SER511 |
| E | ASP513 |
| E | ASN521 |
| E | HIS551 |
| E | TYR553 |
| E | 1UE704 |
| F | ARG469 |
| F | ARG470 |
| site_id | BC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 04J E 702 |
| Chain | Residue |
| E | VAL8 |
| E | VAL9 |
| E | ASP31 |
| E | PHE32 |
| E | PHE35 |
| E | SER36 |
| E | PHE91 |
| E | LEU94 |
| E | ARG97 |
| E | THR172 |
| E | NDP703 |
| site_id | CC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NDP E 703 |
| Chain | Residue |
| E | VAL9 |
| E | ALA10 |
| E | ILE17 |
| E | GLY18 |
| E | ILE19 |
| E | ASN21 |
| E | GLY22 |
| E | LEU23 |
| E | TRP25 |
| E | GLY80 |
| E | ARG81 |
| E | LYS82 |
| E | THR83 |
| E | SER86 |
| E | VAL102 |
| E | SER103 |
| E | SER104 |
| E | GLY153 |
| E | ALA154 |
| E | TYR157 |
| E | 04J702 |
| site_id | CC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1UE E 704 |
| Chain | Residue |
| E | ILE402 |
| E | TRP403 |
| E | ASN406 |
| E | ASP513 |
| E | LEU516 |
| E | GLY517 |
| E | MET608 |
| E | ALA609 |
| E | UMP701 |
| site_id | CC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE UMP F 701 |
| Chain | Residue |
| E | ARG469 |
| E | ARG470 |
| F | CYS489 |
| F | HIS490 |
| F | GLN509 |
| F | ARG510 |
| F | SER511 |
| F | ASP513 |
| F | ASN521 |
| F | HIS551 |
| F | TYR553 |
| F | 1UE704 |
| site_id | CC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 04J F 702 |
| Chain | Residue |
| F | VAL8 |
| F | VAL9 |
| F | ALA10 |
| F | ASP31 |
| F | PHE32 |
| F | PHE35 |
| F | SER36 |
| F | PHE91 |
| F | ARG97 |
| F | NDP703 |
| site_id | CC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NDP F 703 |
| Chain | Residue |
| F | ALA10 |
| F | ILE17 |
| F | GLY18 |
| F | ILE19 |
| F | ASN21 |
| F | GLY22 |
| F | LEU23 |
| F | TRP25 |
| F | GLY80 |
| F | ARG81 |
| F | LYS82 |
| F | THR83 |
| F | SER86 |
| F | VAL102 |
| F | SER103 |
| F | SER104 |
| F | SER105 |
| F | ALA128 |
| F | GLY153 |
| F | ALA154 |
| F | GLY155 |
| F | VAL182 |
| F | 04J702 |
| site_id | CC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1UE F 704 |
| Chain | Residue |
| F | TRP403 |
| F | ASN406 |
| F | ASP513 |
| F | LEU516 |
| F | GLY517 |
| F | PHE520 |
| F | MET608 |
| F | ALA609 |
| F | UMP701 |
| site_id | CC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE UMP G 701 |
| Chain | Residue |
| G | TYR429 |
| G | CYS489 |
| G | HIS490 |
| G | GLN509 |
| G | ARG510 |
| G | SER511 |
| G | ASP513 |
| G | ASN521 |
| G | HIS551 |
| G | TYR553 |
| G | 1UE704 |
| H | ARG469 |
| H | ARG470 |
| site_id | CC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 04J G 702 |
| Chain | Residue |
| G | VAL8 |
| G | VAL9 |
| G | ALA10 |
| G | ASP31 |
| G | PHE32 |
| G | LYS33 |
| G | PHE35 |
| G | SER36 |
| G | PHE91 |
| G | ARG97 |
| G | NDP703 |
| site_id | CC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NDP G 703 |
| Chain | Residue |
| G | VAL9 |
| G | ALA10 |
| G | ILE17 |
| G | GLY18 |
| G | ASN21 |
| G | GLY22 |
| G | GLY80 |
| G | ARG81 |
| G | LYS82 |
| G | THR83 |
| G | SER86 |
| G | VAL102 |
| G | SER103 |
| G | SER104 |
| G | SER105 |
| G | ALA128 |
| G | GLY153 |
| G | ALA154 |
| G | GLY155 |
| G | VAL182 |
| G | 04J702 |
| site_id | DC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1UE G 704 |
| Chain | Residue |
| G | TRP403 |
| G | ASN406 |
| G | ASP513 |
| G | LEU516 |
| G | GLY517 |
| G | ALA609 |
| G | UMP701 |
| site_id | DC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE UMP H 701 |
| Chain | Residue |
| G | ARG469 |
| G | ARG470 |
| H | TYR429 |
| H | CYS489 |
| H | HIS490 |
| H | GLN509 |
| H | ARG510 |
| H | SER511 |
| H | ASP513 |
| H | ASN521 |
| H | HIS551 |
| H | TYR553 |
| H | 1UE704 |
| site_id | DC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 04J H 702 |
| Chain | Residue |
| H | VAL8 |
| H | VAL9 |
| H | ALA10 |
| H | ASP31 |
| H | PHE32 |
| H | PHE35 |
| H | SER36 |
| H | MET87 |
| H | PHE91 |
| H | LEU94 |
| H | ARG97 |
| H | THR172 |
| H | NDP703 |
| site_id | DC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NDP H 703 |
| Chain | Residue |
| H | VAL9 |
| H | ALA10 |
| H | ILE17 |
| H | ILE19 |
| H | ASN21 |
| H | GLY22 |
| H | LEU23 |
| H | TRP25 |
| H | GLY80 |
| H | ARG81 |
| H | LYS82 |
| H | THR83 |
| H | SER86 |
| H | VAL102 |
| H | SER103 |
| H | SER104 |
| H | GLY153 |
| H | ALA154 |
| H | 04J702 |
| site_id | DC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1UE H 704 |
| Chain | Residue |
| H | TRP403 |
| H | ASP513 |
| H | LEU516 |
| H | GLY517 |
| H | MET608 |
| H | ALA609 |
| H | UMP701 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 24 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGinngLPWphlttDfkhFsrvT |
| Chain | Residue | Details |
| A | GLY16-THR39 |
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrmLmtaWNpaaldema.....LpPCHllcQFyV |
| Chain | Residue | Details |
| A | ARG469-VAL497 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS489 | |
| B | CYS489 | |
| C | CYS489 | |
| D | CYS489 | |
| E | CYS489 | |
| F | CYS489 | |
| G | CYS489 | |
| H | CYS489 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 112 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL8 | |
| A | ARG344 | |
| H | ALA10 | |
| H | GLY16 | |
| H | ASP31 | |
| H | ARG81 | |
| H | VAL102 | |
| H | GLY152 | |
| H | TYR157 | |
| H | THR172 | |
| H | ARG344 | |
| H | HIS490 | |
| A | HIS490 | |
| H | GLN509 | |
| H | ASN521 | |
| H | HIS551 | |
| A | GLN509 | |
| A | ASN521 | |
| A | HIS551 | |
| B | VAL8 | |
| B | ALA10 | |
| B | GLY16 | |
| B | ASP31 | |
| B | ARG81 | |
| A | ALA10 | |
| B | VAL102 | |
| B | GLY152 | |
| B | TYR157 | |
| B | THR172 | |
| B | ARG344 | |
| B | HIS490 | |
| B | GLN509 | |
| B | ASN521 | |
| B | HIS551 | |
| C | VAL8 | |
| A | GLY16 | |
| C | ALA10 | |
| C | GLY16 | |
| C | ASP31 | |
| C | ARG81 | |
| C | VAL102 | |
| C | GLY152 | |
| C | TYR157 | |
| C | THR172 | |
| C | ARG344 | |
| C | HIS490 | |
| A | ASP31 | |
| C | GLN509 | |
| C | ASN521 | |
| C | HIS551 | |
| D | VAL8 | |
| D | ALA10 | |
| D | GLY16 | |
| D | ASP31 | |
| D | ARG81 | |
| D | VAL102 | |
| D | GLY152 | |
| A | ARG81 | |
| D | TYR157 | |
| D | THR172 | |
| D | ARG344 | |
| D | HIS490 | |
| D | GLN509 | |
| D | ASN521 | |
| D | HIS551 | |
| E | VAL8 | |
| E | ALA10 | |
| E | GLY16 | |
| A | VAL102 | |
| E | ASP31 | |
| E | ARG81 | |
| E | VAL102 | |
| E | GLY152 | |
| E | TYR157 | |
| E | THR172 | |
| E | ARG344 | |
| E | HIS490 | |
| E | GLN509 | |
| E | ASN521 | |
| A | GLY152 | |
| E | HIS551 | |
| F | VAL8 | |
| F | ALA10 | |
| F | GLY16 | |
| F | ASP31 | |
| F | ARG81 | |
| F | VAL102 | |
| F | GLY152 | |
| F | TYR157 | |
| F | THR172 | |
| A | TYR157 | |
| F | ARG344 | |
| F | HIS490 | |
| F | GLN509 | |
| F | ASN521 | |
| F | HIS551 | |
| G | VAL8 | |
| G | ALA10 | |
| G | GLY16 | |
| G | ASP31 | |
| G | ARG81 | |
| A | THR172 | |
| G | VAL102 | |
| G | GLY152 | |
| G | TYR157 | |
| G | THR172 | |
| G | ARG344 | |
| G | HIS490 | |
| G | GLN509 | |
| G | ASN521 | |
| G | HIS551 | |
| H | VAL8 |
