4EIL

Crystal Structure of the loop truncated Toxoplasma gondii TS-DHFR

Summary for 4EIL

Entry DOI	10.2210/pdb4eil/pdb
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (6 entities in total)
Functional Keywords	bifunctional, oxidoreductase, transferase
Biological source	Toxoplasma gondii
Total number of polymer chains	8
Total formula weight	529494.25
Authors	Sharma, H. (deposition date: 2012-04-05, release date: 2013-10-09, Last modification date: 2023-09-13)
Primary citation	Sharma, H.,Landau, M.J.,Vargo, M.A.,Spasov, K.A.,Anderson, K.S. First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase-Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling. Biochemistry, 52:7305-7317, 2013 Cited by PubMed: 24053355 DOI: 10.1021/bi400576t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1971 Å)

Structure validation