4EIL
Crystal Structure of the loop truncated Toxoplasma gondii TS-DHFR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 566 | 64214.3 | 8 | UniProt (Q07422) Pfam (PF00186) Pfam (PF00303) | Toxoplasma gondii | DHFR-TS, Dihydrofolate reductase, Thymidylate synthase |
| 2 | CA, GA, I, KA, M... (F, G, A, H, B...) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 8 | Chemie (UMP) | |||
| 3 | DA, HA, J, LA, N... (F, G, A, H, B...) | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID | non-polymer | 477.5 | 8 | Chemie (CB3) | |||
| 4 | AA, EA, IA, K, MA... (E, F, G, A, H...) | FOLIC ACID | non-polymer | 441.4 | 8 | Chemie (FOL) | |||
| 5 | BA, FA, JA, L, NA... (E, F, G, A, H...) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 8 | Chemie (NDP) | |||
| 6 | OA, PA, QA, RA, SA... (A, B, C, D, E...) | water | water | 18.0 | 1831 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 610 (UniProt: Q07422)
| PDB | External Database | Details |
|---|---|---|
| - | Arg 48 | deletion |
| - | Leu 49 | deletion |
| - | Asn 50 | deletion |
| - | Gly 51 | deletion |
| - | Trp 52 | deletion |
| - | Leu 53 | deletion |
| - | Pro 54 | deletion |
| - | Arg 55 | deletion |
| - | Lys 56 | deletion |
| - | Phe 57 | deletion |
| - | Ala 58 | deletion |
| - | Lys 59 | deletion |
| - | Thr 60 | deletion |
| - | Gly 61 | deletion |
| - | Asp 62 | deletion |
| - | Ser 63 | deletion |
| - | Gly 64 | deletion |
| - | Leu 65 | deletion |
| - | Pro 66 | deletion |
| - | Ser 67 | deletion |
| - | Pro 68 | deletion |
| - | Ser 69 | deletion |
| - | Val 70 | deletion |
| - | Gly 71 | deletion |
| - | Lys 72 | deletion |
| - | Gln 201 | deletion |
| - | Ala 202 | deletion |
| - | Ala 203 | deletion |
| - | Ala 204 | deletion |
| - | Pro 205 | deletion |
| - | Ala 206 | deletion |
| - | Glu 207 | deletion |
| - | Ser 208 | deletion |
| - | Val 209 | deletion |
| - | Phe 210 | deletion |
| - | Val 211 | deletion |
| - | Pro 212 | deletion |
| - | Phe 213 | deletion |
| - | Cys 214 | deletion |
| - | Pro 215 | deletion |
| - | Glu 216 | deletion |
| - | Leu 217 | deletion |
| - | Gly 218 | deletion |
| - | Arg 219 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 513714.5 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 15779.8 | |
| All* | Total formula weight | 529494.2 |
