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4KYA

Crystal structure of non-classical TS inhibitor 3 in complex with Toxoplasma gondii TS-DHFR

Summary for 4KYA
Entry DOI10.2210/pdb4kya/pdb
Related4EIL 4KY4
DescriptorBifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-Amino-5-(1-naphthylsulfanyl)-3,9-dihydro-4H-pyrimido[4,5-b]indol-4-one, ... (5 entities in total)
Functional Keywordssynthase, bifunctional, chimera protein, oxidoreductase, transferase-inhibitor complex, transferase/inhibitor
Biological sourceToxoplasma gondii
More
Total number of polymer chains8
Total formula weight528541.82
Authors
Sharma, H.,Anderson, K.S. (deposition date: 2013-05-28, release date: 2014-08-06, Last modification date: 2023-09-20)
Primary citationZaware, N.,Sharma, H.,Yang, J.,Devambatla, R.K.,Queener, S.F.,Anderson, K.S.,Gangjee, A.
Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.
ACS Med Chem Lett, 4:1148-1151, 2013
Cited by
PubMed: 24470841
DOI: 10.1021/ml400208v
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.263 Å)
Structure validation

217705

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