4KSG
Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (4-[(1S,5R,6R)-6-AMINO-1-METHYL-3-AZABICYCLO[3.2.0]HEPT-3-YL]-6-FLUORO-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE)
4KSG の概要
エントリーDOI | 10.2210/pdb4ksg/pdb |
関連するPDBエントリー | 4GEE 4K40 4K4O 4KFG 4KQV |
分子名称 | DNA gyrase subunit B, 4-[(1S,5R,6R)-6-amino-1-methyl-3-azabicyclo[3.2.0]hept-3-yl]-6-fluoro-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine, TERTIARY-BUTYL ALCOHOL, ... (4 entities in total) |
機能のキーワード | atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, dna gyrase negatively supercoils closed circular double-stranded dna, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
由来する生物種 | Enterococcus faecalis |
細胞内の位置 | Cytoplasm (By similarity): Q839Z1 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 24358.23 |
構造登録者 | |
主引用文献 | Tari, L.W.,Bensen, D.C.,Finn, J. A new class of type iia topoisomerase inhibitors with broad-spectrum antibacterial activity To be Published, |
実験手法 | X-RAY DIFFRACTION (1.75 Å) |
構造検証レポート
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