4KS5

Influenza neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid

Summary for 4KS5

• Entry DOI: 10.2210/pdb4ks5/pdb
• Related: 4KS1 4KS2 4KS3 4KS4
• Descriptor: Neuraminidase, CALCIUM ION, (3S,4R,5R)-4-(acetylamino)-3-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, ... (4 entities in total)
• Functional Keywords: sialidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus (Influenza Virus)
• Total number of polymer chains: 1
• Total formula weight: 43631.21

Authors

Kerry, P.S.,Russell, R.J.M. (deposition date: 2013-05-17, release date: 2013-10-30, Last modification date: 2023-09-20)

• Primary citation: Kerry, P.S.,Mohan, S.,Russell, R.J.,Bance, N.,Niikura, M.,Pinto, B.M.; Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.; Sci Rep, 3:2871-2871, 2013; PubMed: 24129600; DOI: 10.1038/srep02871

Experimental method

X-RAY DIFFRACTION (2.699 Å)