4KS4
Influenza Neuraminidase in complex with antiviral compound (3S,4R,5R)-4-(acetylamino)-3-{4-[(1R)-1-hydroxypropyl]-1H-1,2,3-triazol-1-yl}-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid
Summary for 4KS4
Entry DOI | 10.2210/pdb4ks4/pdb |
Related | 4KS1 4KS2 4KS3 4KS5 |
Descriptor | Neuraminidase, (3S,4R,5R)-4-(acetylamino)-3-{4-[(1R)-1-hydroxypropyl]-1H-1,2,3-triazol-1-yl}-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | sialidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Influenza A virus (Influenza Virus) |
Cellular location | Host apical cell membrane ; Single-pass type II membrane protein : Q0A480 |
Total number of polymer chains | 1 |
Total formula weight | 43631.21 |
Authors | Kerry, P.S.,Russell, R.J.M. (deposition date: 2013-05-17, release date: 2013-10-30, Last modification date: 2023-12-27) |
Primary citation | Kerry, P.S.,Mohan, S.,Russell, R.J.,Bance, N.,Niikura, M.,Pinto, B.M. Structural basis for a class of nanomolar influenza A neuraminidase inhibitors. Sci Rep, 3:2871-2871, 2013 Cited by PubMed: 24129600DOI: 10.1038/srep02871 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.495 Å) |
Structure validation
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