4KRM

Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5

4KRM の概要

• エントリーDOI: 10.2210/pdb4krm/pdb
• 関連するPDBエントリー: 4KRL 4KRN 4KRO 4KRP
• 分子名称: Epidermal growth factor receptor, Nanobody/VHH domain 7D12, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: cell surface receptor, glycoprotein, nanobody, vhh domain, camelid vh domain, antibody, antigen, antibody complex, transferase-immune system complex, transferase/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 237521.82

構造登録者

Ferguson, K.M.,Schmitz, K.R. (登録日: 2013-05-16, 公開日: 2013-08-28, 最終更新日: 2023-09-20)

• 主引用文献: Schmitz, K.R.,Bagchi, A.,Roovers, R.C.,van Bergen En Henegouwen, P.M.P.,Ferguson, K.M.; Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.; Structure, 21:1214-1224, 2013; PubMed: 23791944; DOI: 10.1016/j.str.2013.05.008

実験手法

X-RAY DIFFRACTION (2.655 Å)