4KQU

Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate

Summary for 4KQU

• Entry DOI: 10.2210/pdb4kqu/pdb
• Related: 4KFA 4KPD 4KPJ 4KQ5 4KQS
• Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: isoprene biosynthesis, lipid synthesis, steroid biosynthesis, transferase, dimethylallyl pyrophosphate, isoprenoid pathway, cholesterol synthesis, bisphosphonates
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43616.96

Authors

Barnett, B.L.,Tsoumpra, M.K.,Muniz, J.R.C.,Walter, R.L. (deposition date: 2013-05-15, release date: 2014-04-30, Last modification date: 2023-09-20)

• Primary citation: Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.,Kavanagh, K.L.,Evdokimov, A.G.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E.; Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate; To be Published,

Experimental method

X-RAY DIFFRACTION (2.07 Å)