4KQU
Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Farnesyl pyrophosphate synthase | polymer | 375 | 43052.9 | 1 | UniProt (P14324) Pfam (PF00348) | Homo sapiens (human) | FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase |
| 2 | B, C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | E (A) | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE | non-polymer | 246.1 | 1 | Chemie (IPE) | |||
| 4 | F (A) | 4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE | non-polymer | 245.1 | 1 | Chemie (AHD) | |||
| 5 | G (A) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 1 - 353 (UniProt: P14324)
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | expression tag |
| Gly -20 | - | expression tag |
| Ser -19 | - | expression tag |
| Ser -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Arg -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Asn -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Tyr -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 204 | Tyr 270 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43052.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 564.1 | |
| All* | Total formula weight | 43617.0 |
