4KQ3

Crystal structure of Anti-IL-17A antibody CNTO3186

Summary for 4KQ3

• Entry DOI: 10.2210/pdb4kq3/pdb
• Related: 4KQ4
• Descriptor: CNTO3186 light chain, CNTO3186 heavy chain, GLYCEROL, ... (6 entities in total)
• Functional Keywords: immunoglobulin fold, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 47957.16

Authors

Teplyakov, A.,Obmolova, G.,Malia, T.,Gilliland, G.L. (deposition date: 2013-05-14, release date: 2014-03-26, Last modification date: 2024-11-06)

Primary citation

Teplyakov, A.,Obmolova, G.,Malia, T.J.,Luo, J.,Gilliland, G.L.
Structural evidence for a constrained conformation of short CDR-L3 in antibodies.
Proteins, 82:1679-1683, 2014

PubMed Abstract: Three Fab structures used as targets in the Antibody Modeling Assessment presented a challenge for modeling CDR-L3 due to deviations from the most typical canonical structure. In all three antibodies CDR-L3 has eight residues, which is one residue shorter than usual, and has a conformation that is rarely observed in crystal structures. We analyzed the sequence and structural determinants of this conformation and found that the "short" CDR-L3 is remarkably rigid and retains the conformation in the interactions with antigens and neighboring CDRs.

PubMed: 24470236
DOI: 10.1002/prot.24522

Experimental method

X-RAY DIFFRACTION (1.92 Å)