4KL1

HCN4 CNBD in complex with cGMP

Summary for 4KL1

Entry DOI	10.2210/pdb4kl1/pdb
Related	1Q3E 3OTF 3U0Z 3U10 3U11 4HBN
Descriptor	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, CYCLIC GUANOSINE MONOPHOSPHATE, ACETATE ION, ... (5 entities in total)
Functional Keywords	cnbd, camp, cgmp, c-di-gmp, c-di-amp, ion channel, hcn, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel, camp binding, cgmp binding, protein transport
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Multi-pass membrane protein: Q9Y3Q4
Total number of polymer chains	4
Total formula weight	96744.53
Authors	Lolicato, M.,Arrigoni, C.,Zucca, S.,Nardini, M.,Bucchi, A.,Schroeder, I.,Simmons, K.,Bolognesi, M.,DiFrancesco, D.,Schwede, F.,Fishwick, C.W.G.,Johnson, A.P.K.,Thiel, G.,Moroni, A. (deposition date: 2013-05-07, release date: 2014-04-30, Last modification date: 2023-12-06)
Primary citation	Lolicato, M.,Bucchi, A.,Arrigoni, C.,Zucca, S.,Nardini, M.,Schroeder, I.,Simmons, K.,Aquila, M.,DiFrancesco, D.,Bolognesi, M.,Schwede, F.,Kashin, D.,Fishwick, C.W.,Johnson, A.P.,Thiel, G.,Moroni, A. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nat.Chem.Biol., 10:457-462, 2014 Cited by PubMed: 24776929 DOI: 10.1038/nchembio.1521 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation