4KL1
HCN4 CNBD in complex with cGMP
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PCG A 801 |
| Chain | Residue |
| A | PHE658 |
| A | LEU711 |
| A | GLY659 |
| A | GLU660 |
| A | ILE661 |
| A | CYS662 |
| A | ARG669 |
| A | THR670 |
| A | ALA671 |
| A | ARG710 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PCG A 802 |
| Chain | Residue |
| A | TYR559 |
| A | LYS562 |
| A | MET563 |
| A | PHE564 |
| A | GLU566 |
| A | PHE613 |
| A | ARG680 |
| A | HOH934 |
| C | HIS541 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 803 |
| Chain | Residue |
| A | GLU579 |
| A | ASN602 |
| A | THR605 |
| A | SER606 |
| C | ARG624 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 804 |
| Chain | Residue |
| A | HIS637 |
| A | GLY638 |
| A | VAL639 |
| A | ASP654 |
| B | LYS651 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 805 |
| Chain | Residue |
| A | LYS651 |
| B | HIS637 |
| B | GLY638 |
| B | VAL639 |
| B | ASP654 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PCG B 801 |
| Chain | Residue |
| B | PHE658 |
| B | GLY659 |
| B | GLU660 |
| B | ILE661 |
| B | CYS662 |
| B | ARG669 |
| B | THR670 |
| B | ALA671 |
| B | ARG710 |
| B | ARG713 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PCG B 802 |
| Chain | Residue |
| A | PHE540 |
| A | HIS541 |
| B | TYR559 |
| B | LYS562 |
| B | MET563 |
| B | PHE564 |
| B | GLU566 |
| B | PHE613 |
| B | ARG680 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PCG C 801 |
| Chain | Residue |
| C | VAL642 |
| C | PHE658 |
| C | GLY659 |
| C | GLU660 |
| C | ILE661 |
| C | CYS662 |
| C | ARG669 |
| C | THR670 |
| C | ALA671 |
| C | ARG710 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PCG C 802 |
| Chain | Residue |
| C | TYR559 |
| C | LYS562 |
| C | MET563 |
| C | PHE564 |
| C | GLU566 |
| C | PHE613 |
| C | ARG680 |
| C | HOH909 |
| C | HOH931 |
| D | HIS541 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 803 |
| Chain | Residue |
| A | ASN602 |
| C | ARG624 |
| C | LYS645 |
| C | SER672 |
| C | HOH912 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 804 |
| Chain | Residue |
| C | GLU575 |
| C | PRO576 |
| C | GLU579 |
| D | TYR621 |
| D | ARG624 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 805 |
| Chain | Residue |
| C | ASP553 |
| C | HIS557 |
| D | ALA653 |
| D | HOH901 |
| site_id | BC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PCG D 801 |
| Chain | Residue |
| D | VAL642 |
| D | PHE658 |
| D | GLY659 |
| D | GLU660 |
| D | ILE661 |
| D | CYS662 |
| D | ARG669 |
| D | THR670 |
| D | ALA671 |
| D | ARG710 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PCG D 802 |
| Chain | Residue |
| D | GLN560 |
| D | LYS562 |
| D | PHE564 |
| D | GLU566 |
| D | PHE613 |
| D | ARG680 |
| D | TYR682 |
| B | HIS541 |
| D | TYR559 |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGTiGKkMYFIqhG |
| Chain | Residue | Details |
| A | ILE622-GLY638 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24776929","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KL1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22006928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23103389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3U11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HBN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9TV66","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22006928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3U11","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
