4KEH

Crosslinked Crystal Structure of Type II Fatty Synthase Dehydratase, FabA, and Acyl Carrier Protein, AcpP

Summary for 4KEH

Related1MKA 2K92
DescriptorN-{3-[DIHYDROXY(NONYL)-LAMBDA~4~-SULFANYL]PROPYL}-N~3~-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANINAMIDE, Acyl carrier protein, N-{3-[dihydroxy(nonyl)-lambda~4~-sulfanyl]propyl}-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... (4 entities in total)
Functional Keywordsfatty acid synthesis, protein-protein complex, dehydratase/isomerase, acyl carrier protein, isomerase-biosynthetic protein complex, isomerase/biosynthetic protein
Biological sourceEscherichia coli
Cellular locationCytoplasm P0A6Q3
Cytoplasm (By similarity) K0BL73
Total number of polymer chains4
Total molecular weight55813.48
Authors
Nguyen, C.,Haushalter, R.,Finzel, K.,Leong, J.,Le, B.C.,Burkart, M.,Tsai, S.C. (deposition date: 2013-04-25, release date: 2013-12-25, Last modification date: 2014-01-29)
Primary citation
Nguyen, C.,Haushalter, R.W.,Lee, D.J.,Markwick, P.R.,Bruegger, J.,Caldara-Festin, G.,Finzel, K.,Jackson, D.R.,Ishikawa, F.,O'Dowd, B.,McCammon, J.A.,Opella, S.J.,Tsai, S.C.,Burkart, M.D.
Trapping the dynamic acyl carrier protein in fatty acid biosynthesis.
Nature, 505:427-431, 2014
PubMed: 24362570 (PDB entries with the same primary citation)
DOI: 10.1038/nature12810
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.901 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.219401.3%13.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4keh
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Molmil generated image of 4keh
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Molmil generated image of 4keh
rotated about y axis by 90°