4KEH
Crosslinked Crystal Structure of Type II Fatty Synthase Dehydratase, FabA, and Acyl Carrier Protein, AcpP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006636 | biological_process | unsaturated fatty acid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| A | 0034017 | molecular_function | trans-2-decenoyl-acyl-carrier-protein isomerase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0006636 | biological_process | unsaturated fatty acid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| B | 0034017 | molecular_function | trans-2-decenoyl-acyl-carrier-protein isomerase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE 1R3 A 201 |
| Chain | Residue |
| A | HIS70 |
| A | HOH356 |
| A | HOH405 |
| A | HOH408 |
| A | HOH418 |
| B | GLN27 |
| B | GLY91 |
| B | ARG104 |
| B | ALA105 |
| B | ARG137 |
| B | HOH375 |
| A | PHE71 |
| C | ASP35 |
| C | SER36 |
| C | LEU37 |
| C | HOH103 |
| A | MET77 |
| A | PRO78 |
| A | GLY79 |
| A | PHE113 |
| A | THR114 |
| A | GLY115 |
| A | GLN116 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 1R3 B 201 |
| Chain | Residue |
| A | GLN27 |
| A | TRP87 |
| A | GLY103 |
| A | ARG104 |
| A | ALA105 |
| A | HOH347 |
| B | HIS70 |
| B | PHE71 |
| B | MET77 |
| B | PRO78 |
| B | GLY79 |
| B | PHE113 |
| B | THR114 |
| B | GLY115 |
| B | GLN116 |
| B | TYR155 |
| B | HOH308 |
| B | HOH328 |
| B | HOH395 |
| D | ASP35 |
| D | SER36 |
| D | LEU37 |
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL |
| Chain | Residue | Details |
| C | ASP31-LEU46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"21276098","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 10 |
| Chain | Residue | Details |
| A | HIS70 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | VAL76 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | GLY79 | electrostatic stabiliser, hydrogen bond donor |
| A | CYS80 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP84 | hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 10 |
| Chain | Residue | Details |
| B | HIS70 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | VAL76 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| B | GLY79 | electrostatic stabiliser, hydrogen bond donor |
| B | CYS80 | electrostatic stabiliser, hydrogen bond donor |
| B | ASP84 | hydrogen bond donor, proton acceptor, proton donor |
