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4K71

Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor

Summary for 4K71
Entry DOI10.2210/pdb4k71/pdb
DescriptorSerum albumin, IgG receptor FcRn large subunit p51, Beta-2-microglobulin, ... (5 entities in total)
Functional Keywordsmhc class i, lipid transport, endosome recycling, endosome
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P02768 P61769
Cell membrane; Single-pass type I membrane protein (By similarity): P55899
Total number of polymer chains6
Total formula weight219084.02
Authors
Schmidt, M.M.,Townson, S.A.,Andreucci, A.,Dombrowski, C.,Erbe, D.V.,King, B.,Kovalchin, J.T.,Masci, A.,Murillo, A.,Schirmer, E.B.,Furfine, E.S.,Barnes, T.M. (deposition date: 2013-04-16, release date: 2013-10-23, Last modification date: 2014-02-05)
Primary citationSchmidt, M.M.,Townson, S.A.,Andreucci, A.J.,King, B.M.,Schirmer, E.B.,Murillo, A.J.,Dombrowski, C.,Tisdale, A.W.,Lowden, P.A.,Masci, A.L.,Kovalchin, J.T.,Erbe, D.V.,Wittrup, K.D.,Furfine, E.S.,Barnes, T.M.
Crystal structure of an HSA/FcRn complex reveals recycling by competitive mimicry of HSA ligands at a pH-dependent hydrophobic interface.
Structure, 21:1966-1978, 2013
Cited by
PubMed: 24120761
DOI: 10.1016/j.str.2013.08.022
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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