4K71
Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009267 | biological_process | cellular response to starvation |
| A | 0015643 | molecular_function | toxic substance binding |
| A | 0015723 | biological_process | bilirubin transport |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0019825 | molecular_function | oxygen binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0031093 | cellular_component | platelet alpha granule lumen |
| A | 0031667 | biological_process | response to nutrient levels |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0042167 | biological_process | heme catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 0051902 | biological_process | negative regulation of mitochondrial depolarization |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072562 | cellular_component | blood microparticle |
| A | 0072732 | biological_process | cellular response to calcium ion starvation |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140104 | molecular_function | molecular carrier activity |
| A | 0140272 | molecular_function | exogenous protein binding |
| A | 1903981 | molecular_function | enterobactin binding |
| C | 0000139 | cellular_component | Golgi membrane |
| C | 0002376 | biological_process | immune system process |
| C | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| C | 0002477 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| C | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| C | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| C | 0002715 | biological_process | regulation of natural killer cell mediated immunity |
| C | 0002726 | biological_process | positive regulation of T cell cytokine production |
| C | 0005198 | molecular_function | structural molecule activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005765 | cellular_component | lysosomal membrane |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005788 | cellular_component | endoplasmic reticulum lumen |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005925 | cellular_component | focal adhesion |
| C | 0006879 | biological_process | intracellular iron ion homeostasis |
| C | 0006955 | biological_process | immune response |
| C | 0007608 | biological_process | sensory perception of smell |
| C | 0007611 | biological_process | learning or memory |
| C | 0009897 | cellular_component | external side of plasma membrane |
| C | 0009986 | cellular_component | cell surface |
| C | 0010038 | biological_process | response to metal ion |
| C | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| C | 0016020 | cellular_component | membrane |
| C | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| C | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| C | 0023026 | molecular_function | MHC class II protein complex binding |
| C | 0030670 | cellular_component | phagocytic vesicle membrane |
| C | 0031901 | cellular_component | early endosome membrane |
| C | 0031902 | cellular_component | late endosome membrane |
| C | 0031905 | cellular_component | early endosome lumen |
| C | 0033572 | biological_process | transferrin transport |
| C | 0034756 | biological_process | regulation of iron ion transport |
| C | 0034757 | biological_process | negative regulation of iron ion transport |
| C | 0035580 | cellular_component | specific granule lumen |
| C | 0042605 | molecular_function | peptide antigen binding |
| C | 0042612 | cellular_component | MHC class I protein complex |
| C | 0042613 | cellular_component | MHC class II protein complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0042824 | cellular_component | MHC class I peptide loading complex |
| C | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| C | 0048261 | biological_process | negative regulation of receptor-mediated endocytosis |
| C | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| C | 0050768 | biological_process | negative regulation of neurogenesis |
| C | 0050778 | biological_process | positive regulation of immune response |
| C | 0050870 | biological_process | positive regulation of T cell activation |
| C | 0051289 | biological_process | protein homotetramerization |
| C | 0055038 | cellular_component | recycling endosome membrane |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0071281 | biological_process | cellular response to iron ion |
| C | 0071316 | biological_process | cellular response to nicotine |
| C | 1904724 | cellular_component | tertiary granule lumen |
| C | 1990000 | biological_process | amyloid fibril formation |
| C | 1990712 | cellular_component | HFE-transferrin receptor complex |
| C | 2000774 | biological_process | positive regulation of cellular senescence |
| C | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
| D | 0003677 | molecular_function | DNA binding |
| D | 0005504 | molecular_function | fatty acid binding |
| D | 0005507 | molecular_function | copper ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005788 | cellular_component | endoplasmic reticulum lumen |
| D | 0006783 | biological_process | heme biosynthetic process |
| D | 0008289 | molecular_function | lipid binding |
| D | 0009267 | biological_process | cellular response to starvation |
| D | 0015643 | molecular_function | toxic substance binding |
| D | 0015723 | biological_process | bilirubin transport |
| D | 0016209 | molecular_function | antioxidant activity |
| D | 0019825 | molecular_function | oxygen binding |
| D | 0020037 | molecular_function | heme binding |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0031093 | cellular_component | platelet alpha granule lumen |
| D | 0031667 | biological_process | response to nutrient levels |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0034599 | biological_process | cellular response to oxidative stress |
| D | 0042167 | biological_process | heme catabolic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051087 | molecular_function | protein-folding chaperone binding |
| D | 0051902 | biological_process | negative regulation of mitochondrial depolarization |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0072562 | cellular_component | blood microparticle |
| D | 0072732 | biological_process | cellular response to calcium ion starvation |
| D | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0140104 | molecular_function | molecular carrier activity |
| D | 0140272 | molecular_function | exogenous protein binding |
| D | 1903981 | molecular_function | enterobactin binding |
| F | 0000139 | cellular_component | Golgi membrane |
| F | 0002376 | biological_process | immune system process |
| F | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| F | 0002477 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| F | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| F | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| F | 0002715 | biological_process | regulation of natural killer cell mediated immunity |
| F | 0002726 | biological_process | positive regulation of T cell cytokine production |
| F | 0005198 | molecular_function | structural molecule activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005615 | cellular_component | extracellular space |
| F | 0005765 | cellular_component | lysosomal membrane |
| F | 0005783 | cellular_component | endoplasmic reticulum |
| F | 0005788 | cellular_component | endoplasmic reticulum lumen |
| F | 0005794 | cellular_component | Golgi apparatus |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0005925 | cellular_component | focal adhesion |
| F | 0006879 | biological_process | intracellular iron ion homeostasis |
| F | 0006955 | biological_process | immune response |
| F | 0007608 | biological_process | sensory perception of smell |
| F | 0007611 | biological_process | learning or memory |
| F | 0009897 | cellular_component | external side of plasma membrane |
| F | 0009986 | cellular_component | cell surface |
| F | 0010038 | biological_process | response to metal ion |
| F | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| F | 0016020 | cellular_component | membrane |
| F | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| F | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| F | 0023026 | molecular_function | MHC class II protein complex binding |
| F | 0030670 | cellular_component | phagocytic vesicle membrane |
| F | 0031901 | cellular_component | early endosome membrane |
| F | 0031902 | cellular_component | late endosome membrane |
| F | 0031905 | cellular_component | early endosome lumen |
| F | 0033572 | biological_process | transferrin transport |
| F | 0034756 | biological_process | regulation of iron ion transport |
| F | 0034757 | biological_process | negative regulation of iron ion transport |
| F | 0035580 | cellular_component | specific granule lumen |
| F | 0042605 | molecular_function | peptide antigen binding |
| F | 0042612 | cellular_component | MHC class I protein complex |
| F | 0042613 | cellular_component | MHC class II protein complex |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0042803 | molecular_function | protein homodimerization activity |
| F | 0042824 | cellular_component | MHC class I peptide loading complex |
| F | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| F | 0048261 | biological_process | negative regulation of receptor-mediated endocytosis |
| F | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| F | 0050768 | biological_process | negative regulation of neurogenesis |
| F | 0050778 | biological_process | positive regulation of immune response |
| F | 0050870 | biological_process | positive regulation of T cell activation |
| F | 0051289 | biological_process | protein homotetramerization |
| F | 0055038 | cellular_component | recycling endosome membrane |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 0071281 | biological_process | cellular response to iron ion |
| F | 0071316 | biological_process | cellular response to nicotine |
| F | 1904724 | cellular_component | tertiary granule lumen |
| F | 1990000 | biological_process | amyloid fibril formation |
| F | 1990712 | cellular_component | HFE-transferrin receptor complex |
| F | 2000774 | biological_process | positive regulation of cellular senescence |
| F | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 601 |
| Chain | Residue |
| A | PRO282 |
| A | LEU283 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | HIS9 |
| A | LYS12 |
| A | GLU57 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| A | ALA59 |
| A | GLU60 |
| E | ARG214 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 604 |
| Chain | Residue |
| A | HIS9 |
| A | ARG10 |
| A | HIS3 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | TYR150 |
| A | LEU238 |
| A | HIS242 |
| A | ARG257 |
| A | ALA291 |
| A | HOH708 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 606 |
| Chain | Residue |
| A | PHE206 |
| A | LYS351 |
| A | SER480 |
| A | LEU481 |
| A | VAL482 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 607 |
| Chain | Residue |
| A | HIS146 |
| A | SER193 |
| A | ALA194 |
| A | GLN459 |
| A | HOH705 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| B | ASN39 |
| B | ARG42 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | SER181 |
| B | ARG183 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 101 |
| Chain | Residue |
| C | ARG3 |
| C | THR4 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 102 |
| Chain | Residue |
| C | SER57 |
| C | LYS58 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 601 |
| Chain | Residue |
| B | ARG264 |
| D | ASN44 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 602 |
| Chain | Residue |
| D | PHE156 |
| D | LYS159 |
| D | ARG160 |
| D | LYS281 |
| D | GLU285 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 603 |
| Chain | Residue |
| B | ARG214 |
| D | ALA59 |
| D | GLU60 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 604 |
| Chain | Residue |
| D | TYR150 |
| D | LEU238 |
| D | HIS242 |
| D | ARG257 |
| D | ALA291 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 605 |
| Chain | Residue |
| D | PHE206 |
| D | LYS351 |
| D | SER480 |
| D | LEU481 |
| D | VAL482 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 606 |
| Chain | Residue |
| D | LYS195 |
| D | LYS199 |
| D | TRP214 |
| D | ARG218 |
| D | ARG222 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 E 301 |
| Chain | Residue |
| E | SER181 |
| E | ARG183 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 101 |
| Chain | Residue |
| F | LYS41 |
| F | PHE70 |
| F | THR71 |
| F | TYR78 |
Functional Information from PROSITE/UniProt
| site_id | PS00212 |
| Number of Residues | 25 |
| Details | ALBUMIN_1 Albumin domain signature. YkaafteCCqaAdkaaCLlpkldeL |
| Chain | Residue | Details |
| A | TYR161-LEU185 | |
| A | TYR353-PHE377 | |
| A | PHE551-LEU575 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YCCIVQH |
| Chain | Residue | Details |
| B | TYR250-HIS256 | |
| C | TYR78-HIS84 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 384 |
| Details | Domain: {"description":"Albumin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00769","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 197 |
| Details | Domain: {"description":"Albumin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00769","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P02770","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P02769","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28567254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IJF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"656055","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 72 |
| Details | Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"15047055","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Site: {"description":"Aspirin-acetylated lysine"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18318008","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 7 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P07724","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07724","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"3759977","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 26 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"15047055","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"3759977","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6853480","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"15047055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3759977","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; in variant Redhill","featureId":"CAR_000226"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; in variant Casebrook","featureId":"CAR_000069"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"15047055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3759977","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6706980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6853480","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; alternate","evidences":[{"source":"PubMed","id":"3759977","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 174 |
| Details | Domain: {"description":"Ig-like C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 178 |
| Details | Region: {"description":"Alpha-2","evidences":[{"source":"PubMed","id":"10933786","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 178 |
| Details | Region: {"description":"Alpha-3","evidences":[{"source":"PubMed","id":"10933786","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 176 |
| Details | Domain: {"description":"Ig-like C1-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI34 |
| Number of Residues | 12 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
