4K71
Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Serum albumin | polymer | 585 | 66473.1 | 2 | UniProt (P02768) Pfam (PF00273) | Homo sapiens (human) | |
| 2 | B, E (B, E) | IgG receptor FcRn large subunit p51 | polymer | 274 | 30408.1 | 2 | UniProt (P55899) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (human) | FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor |
| 3 | C, F (C, F) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 2 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
| 4 | G, H, I, J, K... (A, B, C, D, E...) | SULFATE ION | non-polymer | 96.1 | 19 | Chemie (SO4) | |||
| 5 | AA, BA, CA, DA, EA... (B, C, D, E, F...) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 585 (UniProt: P02768)
| PDB | External Database | Details |
|---|---|---|
| Met 418 | Val 442 | engineered mutation |
| Ala 420 | Thr 444 | engineered mutation |
| Gly 505 | Glu 529 | engineered mutation |
| Ala 547 | Val 571 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 217258.8 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1825.2 | |
| All* | Total formula weight | 219084.0 |
