4K71
Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Serum albumin | polymer | 585 | 66473.1 | 2 | UniProt (P02768) Pfam (PF00273) In PDB | Homo sapiens (human) | |
2 | B, E | IgG receptor FcRn large subunit p51 | polymer | 274 | 30408.1 | 2 | UniProt (P55899) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (human) | FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor |
3 | C, F | Beta-2-microglobulin | polymer | 99 | 11748.2 | 2 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
4 | A, B, C, D, E... | SULFATE ION | non-polymer | 96.1 | 19 | Chemie (SO4) | |||
5 | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 585 (UniProt: P02768)
PDB | External Database | Details |
---|---|---|
Met 418 | Val 442 | ENGINEERED MUTATION |
Ala 420 | Thr 444 | ENGINEERED MUTATION |
Gly 505 | Glu 529 | ENGINEERED MUTATION |
Ala 547 | Val 571 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 217258.8 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 1825.2 | |
All* | Total formula weight | 219084.0 |