4K10
Crystal Structure of Leshmaniasis major Farnesyl diphosphate synthase in complex with 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM and Mg2+
Summary for 4K10
| Entry DOI | 10.2210/pdb4k10/pdb |
| Related | 4JZB 4JZX |
| Descriptor | Farnesyl pyrophosphate synthase, SODIUM ION, MAGNESIUM ION, ... (8 entities in total) |
| Functional Keywords | geranyl transferase, fpps, farnesyl pyrophosphate synthase, farnesyl diphosphate synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Leishmania major |
| Total number of polymer chains | 4 |
| Total formula weight | 166029.05 |
| Authors | Aripirala, S.,Gabelli, S.,Amzel, L.M. (deposition date: 2013-04-04, release date: 2014-04-02, Last modification date: 2024-02-28) |
| Primary citation | Aripirala, S.,Gonzalez-Pacanowska, D.,Oldfield, E.,Kaiser, M.,Amzel, L.M.,Gabelli, S.B. Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates. Acta Crystallogr.,Sect.D, 70:802-810, 2014 Cited by PubMed: 24598749DOI: 10.1107/S1399004713033221 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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