Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4K10

Crystal Structure of Leshmaniasis major Farnesyl diphosphate synthase in complex with 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM and Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004161	molecular_function	dimethylallyltranstransferase activity
A	0004337	molecular_function	geranyltranstransferase activity
A	0004659	molecular_function	prenyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0045337	biological_process	farnesyl diphosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0004161	molecular_function	dimethylallyltranstransferase activity
B	0004337	molecular_function	geranyltranstransferase activity
B	0004659	molecular_function	prenyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0045337	biological_process	farnesyl diphosphate biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0004161	molecular_function	dimethylallyltranstransferase activity
C	0004337	molecular_function	geranyltranstransferase activity
C	0004659	molecular_function	prenyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0045337	biological_process	farnesyl diphosphate biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0004161	molecular_function	dimethylallyltranstransferase activity
D	0004337	molecular_function	geranyltranstransferase activity
D	0004659	molecular_function	prenyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0045337	biological_process	farnesyl diphosphate biosynthetic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 401

Chain	Residue
A	HOH531
B	HOH555

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 402

Chain	Residue
A	HIS157
A	ASP160
A	HOH521
B	ALA133
B	HOH509

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 403

Chain	Residue
B	HOH538

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 404

Chain	Residue
A	NI9406
A	HOH503
A	HOH510
A	HOH511
A	HOH512
A	HOH560
A	ASP250

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 405

Chain	Residue
A	ASP98
A	ASP102
A	NI9406
A	HOH517

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE NI9 A 406

Chain	Residue
A	LEU95
A	ASP98
A	ARG107
A	GLN167
A	LYS207
A	TYR211
A	LYS273
A	MG404
A	MG405
A	HOH503
A	HOH560
A	HOH563

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 401

Chain	Residue
A	ALA133
A	HOH527
B	HIS157
B	ASP160

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 407

Chain	Residue
A	LYS233
A	HIS236
D	VAL30
D	LYS33
D	GLY34
D	LYS37

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT B 402

Chain	Residue
B	LYS48
B	TYR49
B	GLN91
B	HOH529

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 403

Chain	Residue
B	ASP250
B	LYS273
B	HOH503
B	HOH507

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 404

Chain	Residue
B	ASP98
B	ASP102
B	NI9405
B	HOH558
B	HOH560

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE NI9 B 405

Chain	Residue
B	ASP98
B	GLN167
B	ASP170
B	LYS207
B	TYR211
B	MG404
B	HOH502
B	HOH507
B	HOH560
B	HOH570

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MES D 401

Chain	Residue
C	ARG154
C	ASP158
D	HIS141
D	ALA144
D	HOH506
D	HOH541

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT D 402

Chain	Residue
D	ALA2
D	HIS3
D	GLU60
D	LYS64

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 403

Chain	Residue
D	ASP250
D	HOH501
D	HOH502
D	HOH503
D	HOH517

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 404

Chain	Residue
D	ASP98
D	ASP102
D	NI9405
D	HOH504
D	HOH551
D	HOH553

site_id	BC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE NI9 D 405

Chain	Residue
D	ASP98
D	ARG107
D	GLN167
D	LYS207
D	TYR211
D	MG404
D	HOH502
D	HOH504
D	HOH554
D	HOH558

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA C 401

Chain	Residue
D	HOH507
C	HIS157
C	ASP160
C	HOH501
D	ALA133

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 403

Chain	Residue
C	ASP250
C	NI9405
C	HOH504
C	HOH505
C	HOH563
C	HOH570

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 404

Chain	Residue
C	ASP98
C	ASP102
C	NI9405
C	HOH561

site_id	CC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE NI9 C 405

Chain	Residue
C	PHE94
C	LEU95
C	ASP98
C	ARG107
C	GLN167
C	LYS207
C	TYR211
C	LYS273
C	MG403
C	MG404
C	HOH533
C	HOH561
C	HOH571

Functional Information from PROSITE/UniProt

site_id	PS00444
Number of Residues	13
Details	POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGeyFQVqDDVmD

Chain	Residue	Details
A	MET242-ASP254

site_id	PS00723
Number of Residues	15
Details	POLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVeDDim..DhsktRRG

Chain	Residue	Details
A	LEU95-GLY109

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)