4JYU
Structure of factor VIIA in complex with the inhibitor (2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-[3-ETHOXY-4-(PROPAN-2-YLOXY)PHENYL]-N-(PHENYLSULFONYL)ETHANAMIDE
Summary for 4JYU
Entry DOI | 10.2210/pdb4jyu/pdb |
Related | 4JYV |
Descriptor | Factor VII light chain, Factor VII heavy chain, (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-(phenylsulfonyl)ethanamide, ... (7 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 35461.42 |
Authors | Wei, A.,Anumula, R. (deposition date: 2013-04-01, release date: 2013-07-24, Last modification date: 2013-09-11) |
Primary citation | Glunz, P.W.,Zhang, X.,Zou, Y.,Delucca, I.,Nirschl, A.H.,Cheng, X.,Weigelt, C.A.,Cheney, D.L.,Wei, A.,Anumula, R.,Luettgen, J.M.,Rendina, A.R.,Harpel, M.,Luo, G.,Knabb, R.,Wong, P.C.,Wexler, R.R.,Priestley, E.S. Nonbenzamidine acylsulfonamide tissue factor-factor VIIa inhibitors. Bioorg.Med.Chem.Lett., 23:5244-5248, 2013 Cited by PubMed: 23845220DOI: 10.1016/j.bmcl.2013.06.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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