4JYV

Structure of factor VIIA in complex with the inhibitor (2R)-2-[3-ETHOXY-4-(PROPAN-2-YLOXY)PHENYL]-2-(ISOQUINOLIN-6-YLAMINO)-N-[(3-SULFAMOYLPHENYL)SULFONYL]ETHANAMIDE

Summary for 4JYV

• Entry DOI: 10.2210/pdb4jyv/pdb
• Related: 4JYU
• Descriptor: Factor VII light chain, Factor VII heavy chain, (2R)-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-2-(isoquinolin-6-ylamino)-N-[(3-sulfamoylphenyl)sulfonyl]ethanamide, ... (7 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 35525.48

Authors

Wei, A.,Anumula, R. (deposition date: 2013-04-01, release date: 2013-07-24, Last modification date: 2013-09-11)

• Primary citation: Glunz, P.W.,Zhang, X.,Zou, Y.,Delucca, I.,Nirschl, A.H.,Cheng, X.,Weigelt, C.A.,Cheney, D.L.,Wei, A.,Anumula, R.,Luettgen, J.M.,Rendina, A.R.,Harpel, M.,Luo, G.,Knabb, R.,Wong, P.C.,Wexler, R.R.,Priestley, E.S.; Nonbenzamidine acylsulfonamide tissue factor-factor VIIa inhibitors.; Bioorg.Med.Chem.Lett., 23:5244-5248, 2013; PubMed: 23845220; DOI: 10.1016/j.bmcl.2013.06.027

Experimental method

X-RAY DIFFRACTION (2.19 Å)