4JYU
Structure of factor VIIA in complex with the inhibitor (2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-[3-ETHOXY-4-(PROPAN-2-YLOXY)PHENYL]-N-(PHENYLSULFONYL)ETHANAMIDE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Factor VII light chain | polymer | 254 | 28103.3 | 1 | UniProt (P08709) Pfam (PF00089) | Homo sapiens (human) | Proconvertin, Serum prothrombin conversion accelerator, SPCA, Coagulation factor VII |
| 2 | B (L) | Factor VII heavy chain | polymer | 55 | 6030.8 | 1 | UniProt (P08709) Pfam (PF14670) | Homo sapiens (human) | Proconvertin, Serum prothrombin conversion accelerator, SPCA, Coagulation factor VII |
| 3 | C (H) | (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-(phenylsulfonyl)ethanamide | non-polymer | 534.6 | 1 | Chemie (1OK) | |||
| 4 | D (H) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E, F, G, H (H) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | I, J, K, L (H) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | M, N (H, L) | water | water | 18.0 | 374 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34134.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1327.3 | |
| All* | Total formula weight | 35461.4 |
