4JXV
X-ray crystal structure of AmpC beta-lactamase from E. coli in complex with a non-covalent inhibitor 3-{[2-(4-CARBOXYPHENYL)ETHYL]SULFAMOYL}THIOPHENE-2-CARBOXYLIC ACID (compound 5)
Summary for 4JXV
Entry DOI | 10.2210/pdb4jxv/pdb |
Related | 1L2S 1XGI 1XGJ 4JXS 4JXW |
Descriptor | Beta-lactamase, 3-{[2-(4-carboxyphenyl)ethyl]sulfamoyl}thiophene-2-carboxylic acid, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | cephalosporinase, beta-lactamase, serine hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli |
Cellular location | Periplasm: P00811 |
Total number of polymer chains | 2 |
Total formula weight | 79981.59 |
Authors | Powers, R.A.,Hendershot, J.M. (deposition date: 2013-03-28, release date: 2014-04-30, Last modification date: 2024-02-28) |
Primary citation | Hendershot, J.M.,Mishra, U.J.,Smart, R.P.,Schroeder, W.,Powers, R.A. Structure-based efforts to optimize a non-beta-lactam inhibitor of AmpC beta-lactamase. Bioorg.Med.Chem., 22:3351-3359, 2014 Cited by PubMed: 24835785DOI: 10.1016/j.bmc.2014.04.051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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