1XGI
AmpC beta-lactamase in complex with 3-(3-nitro-phenylsulfamoyl)-thiophene-2-carboxylic acid
Summary for 1XGI
Entry DOI | 10.2210/pdb1xgi/pdb |
Related | 1KE4 1L2S 1XGJ |
Descriptor | Beta-lactamase, 3-{[(3-NITROANILINE]SULFONYL}THIOPHENE-2-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | ampc, beta-lactamase, cephalosporinase, serine hydrolase, hydrolase |
Biological source | Escherichia coli |
Cellular location | Periplasm: P00811 |
Total number of polymer chains | 2 |
Total formula weight | 79504.16 |
Authors | Tondi, D.,Morandi, F.,Bonnet, R.,Costi, M.P.,Shoichet, B.K. (deposition date: 2004-09-17, release date: 2005-05-03, Last modification date: 2023-08-23) |
Primary citation | Tondi, D.,Morandi, F.,Bonnet, R.,Costi, M.P.,Shoichet, B.K. Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture. J.Am.Chem.Soc., 127:4632-4639, 2005 Cited by PubMed: 15796528DOI: 10.1021/ja042984o PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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