4JXW

X-ray crystal structure of AmpC beta-lactamase from E. coli in complex with a non-covalent inhibitor 3-{[3-(4-CARBOXYPHENYL)PROPYL]SULFAMOYL}THIOPHENE-2-CARBOXYLIC ACID (compound 6)

Summary for 4JXW

Entry DOI	10.2210/pdb4jxw/pdb
Related	1L2S 1XGI 1XGJ 4JXS 4JXV
Descriptor	Beta-lactamase, 3-{[3-(4-carboxyphenyl)propyl]sulfamoyl}thiophene-2-carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	cephalosporinase, beta-lactamase, serine hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli
Cellular location	Periplasm: P00811
Total number of polymer chains	2
Total formula weight	80009.64
Authors	Powers, R.A.,Hendershot, J.M. (deposition date: 2013-03-28, release date: 2014-05-07, Last modification date: 2024-02-28)
Primary citation	Hendershot, J.M.,Mishra, U.J.,Smart, R.P.,Schroeder, W.,Powers, R.A. Structure-based efforts to optimize a non-beta-lactam inhibitor of AmpC beta-lactamase. Bioorg.Med.Chem., 22:3351-3359, 2014 Cited by PubMed: 24835785 DOI: 10.1016/j.bmc.2014.04.051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation