4JSC

The 2.5A crystal structure of humanized Xenopus MDM2 with RO5316533 - a pyrrolidine MDM2 inhibitor

Summary for 4JSC

Entry DOI	10.2210/pdb4jsc/pdb
Related	4IPF 4JRG
Descriptor	E3 ubiquitin-protein ligase Mdm2, (3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-N-[(3S)-3,4-dihydroxybutyl]-5-(2,2-dimethylpropyl)-D-prolinamide (3 entities in total)
Functional Keywords	pyrrolidine, ligase-antagonist complex, e3 ubiquitin ligase, p53, nucleus, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Xenopus laevis (clawed frog,common platanna,platanna)
Cellular location	Nucleus, nucleoplasm (By similarity): P56273
Total number of polymer chains	2
Total formula weight	21034.14
Authors	Janson, C.A.,Lukacs, C.,Graves, B. (deposition date: 2013-03-22, release date: 2013-07-24, Last modification date: 2024-02-28)
Primary citation	Ding, Q.,Zhang, Z.,Liu, J.J.,Jiang, N.,Zhang, J.,Ross, T.M.,Chu, X.J.,Bartkovitz, D.,Podlaski, F.,Janson, C.,Tovar, C.,Filipovic, Z.M.,Higgins, B.,Glenn, K.,Packman, K.,Vassilev, L.T.,Graves, B. Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development. J.Med.Chem., 56:5979-5983, 2013 Cited by PubMed: 23808545 DOI: 10.1021/jm400487c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation