4JSC
The 2.5A crystal structure of humanized Xenopus MDM2 with RO5316533 - a pyrrolidine MDM2 inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1OY A 201 |
| Chain | Residue |
| A | LEU50 |
| A | TYR96 |
| B | GLU86 |
| A | LEU53 |
| A | GLY54 |
| A | MET58 |
| A | HIS69 |
| A | VAL89 |
| A | LYS90 |
| A | HIS92 |
| A | ILE95 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1OY B 201 |
| Chain | Residue |
| A | GLU86 |
| B | LEU50 |
| B | HIS69 |
| B | PHE82 |
| B | VAL89 |
| B | LYS90 |
| B | HIS92 |
| B | ILE95 |
| B | TYR96 |
