4JQH
Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain
Summary for 4JQH
Entry DOI | 10.2210/pdb4jqh/pdb |
Related | 3L6J 4IAE 4IAH 4IAM |
Descriptor | Alr2278 protein, 4-{[(4-carboxybutyl)(2-{2-[(4'-phenoxybiphenyl-4-yl)methoxy]phenyl}ethyl)amino]methyl}benzoic acid, MALONIC ACID, ... (4 entities in total) |
Functional Keywords | guanylyl cyclase, analogue of bay58-2667, signaling protein |
Biological source | Nostoc sp. |
Total number of polymer chains | 2 |
Total formula weight | 43830.76 |
Authors | Kumar, V.,van den Akker, F. (deposition date: 2013-03-20, release date: 2013-11-20, Last modification date: 2024-02-28) |
Primary citation | von Wantoch Rekowski, M.,Kumar, V.,Zhou, Z.,Moschner, J.,Marazioti, A.,Bantzi, M.,Spyroulias, G.A.,van den Akker, F.,Giannis, A.,Papapetropoulos, A. Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics. J.Med.Chem., 56:8948-8952, 2013 Cited by PubMed: 24090476DOI: 10.1021/jm400539d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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