4JQH
Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Alr2278 protein | polymer | 189 | 21181.6 | 2 | UniProt (Q8YUQ7) Pfam (PF07700) In PDB | Nostoc sp. | |
| 2 | A, B | 4-{[(4-carboxybutyl)(2-{2-[(4'-phenoxybiphenyl-4-yl)methoxy]phenyl}ethyl)amino]methyl}benzoic acid | non-polymer | 629.7 | 2 | Chemie (1MF) | |||
| 3 | A, B | MALONIC ACID | non-polymer | 104.1 | 2 | Chemie (MLA) | |||
| 4 | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 189 (UniProt: Q8YUQ7)
| PDB | External Database | Details |
|---|---|---|
| Ala 139 | Cys 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42363.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1467.6 | |
| All* | Total formula weight | 43830.8 |
