4JQH
Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004383 | molecular_function | guanylate cyclase activity |
A | 0006182 | biological_process | cGMP biosynthetic process |
A | 0008074 | cellular_component | guanylate cyclase complex, soluble |
A | 0019934 | biological_process | cGMP-mediated signaling |
A | 0020037 | molecular_function | heme binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0070482 | biological_process | response to oxygen levels |
B | 0004383 | molecular_function | guanylate cyclase activity |
B | 0006182 | biological_process | cGMP biosynthetic process |
B | 0008074 | cellular_component | guanylate cyclase complex, soluble |
B | 0019934 | biological_process | cGMP-mediated signaling |
B | 0020037 | molecular_function | heme binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0070482 | biological_process | response to oxygen levels |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 1MF A 201 |
Chain | Residue |
A | MET1 |
A | VAL108 |
A | SER111 |
A | PHE112 |
A | LEU115 |
A | ARG116 |
A | PRO118 |
A | TYR134 |
A | SER136 |
A | ARG138 |
A | LEU148 |
A | TYR2 |
A | HOH308 |
A | HOH312 |
A | MET40 |
A | TRP74 |
A | TYR83 |
A | PHE97 |
A | LEU101 |
A | HIS105 |
A | ARG107 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MLA A 202 |
Chain | Residue |
A | HIS16 |
A | HIS17 |
A | LYS61 |
A | LEU66 |
A | ALA69 |
A | HOH354 |
site_id | AC3 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 1MF B 201 |
Chain | Residue |
B | MET1 |
B | TYR2 |
B | LEU4 |
B | MET40 |
B | TRP74 |
B | TYR83 |
B | PHE97 |
B | LEU101 |
B | HIS105 |
B | ARG107 |
B | VAL108 |
B | SER111 |
B | PHE112 |
B | ARG116 |
B | PRO118 |
B | TYR134 |
B | SER136 |
B | ARG138 |
B | LEU141 |
B | LEU148 |
B | HOH319 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MLA B 202 |
Chain | Residue |
B | MET12 |
B | HIS16 |
B | HIS17 |
B | LYS61 |
B | LEU66 |