4JI9

JAK2 kinase (JH1 domain) in complex with TG101209

Summary for 4JI9

• Entry DOI: 10.2210/pdb4ji9/pdb
• Related: 4JIA
• Descriptor: Tyrosine-protein kinase JAK2, N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide (3 entities in total)
• Functional Keywords: protein kinase, phospho-transfer catalyst, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Endomembrane system; Peripheral membrane protein (By similarity): O60674
• Total number of polymer chains: 2
• Total formula weight: 71703.58

Authors

Eigenbrot, C.,Ultsch, M. (deposition date: 2013-03-05, release date: 2013-08-07, Last modification date: 2024-11-27)

Primary citation

Siu, M.,Pastor, R.,Liu, W.,Barrett, K.,Berry, M.,Blair, W.S.,Chang, C.,Chen, J.Z.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,He, H.,Hurley, C.A.,Kenny, J.R.,Cyrus Khojasteh, S.,Le, H.,Lee, L.,Lyssikatos, J.P.,Magnuson, S.,Pulk, R.,Tsui, V.,Ultsch, M.,Xiao, Y.,Zhu, B.Y.,Sampath, D.
2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.
Bioorg.Med.Chem.Lett., 23:5014-5021, 2013

PubMed Abstract: The advancement of a series of ligand efficient 2-amino-[1,2,4]triazolo[1,5-a]pyridines, initially identified from high-throughput screening, to a JAK2 inhibitor with pharmacodynamic activity in a mouse xenograft model is disclosed.

PubMed: 23870430
DOI: 10.1016/j.bmcl.2013.06.008

Experimental method

X-RAY DIFFRACTION (2.4 Å)