4JIA

JAK2 kinase (JH1 domain) in complex with compound 9

Summary for 4JIA

• Entry DOI: 10.2210/pdb4jia/pdb
• Related: 4JI9
• Descriptor: Tyrosine-protein kinase JAK2, 5-(4-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine, GLYCEROL, ... (4 entities in total)
• Functional Keywords: protein kinase, phosphotransfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Endomembrane system; Peripheral membrane protein (By similarity): O60674
• Total number of polymer chains: 1
• Total formula weight: 35848.72

Authors

Eigenbrot, C.,Ultsch, M. (deposition date: 2013-03-05, release date: 2013-08-07, Last modification date: 2023-12-06)

• Primary citation: Siu, M.,Pastor, R.,Liu, W.,Barrett, K.,Berry, M.,Blair, W.S.,Chang, C.,Chen, J.Z.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,He, H.,Hurley, C.A.,Kenny, J.R.,Cyrus Khojasteh, S.,Le, H.,Lee, L.,Lyssikatos, J.P.,Magnuson, S.,Pulk, R.,Tsui, V.,Ultsch, M.,Xiao, Y.,Zhu, B.Y.,Sampath, D.; 2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.; Bioorg.Med.Chem.Lett., 23:5014-5021, 2013; PubMed: 23870430; DOI: 10.1016/j.bmcl.2013.06.008

Experimental method

X-RAY DIFFRACTION (1.85 Å)